Synthesis and Antimicrobial Screening of Some Substituted 1,3,4-Oxadiazole Derivatives

Authors

  • P. D. Gokulan Professor, Department of Pharmaceutical Chemistry, Sri Vijay Vidyalaya College of Pharmacy, Dharmapuri, India
  • K. L. Senthil Kumar Principal, Department of Pharmaceutics, Sri Vijay Vidyalaya College of Pharmacy, Dharmapuri, India
  • V. Suresh Professor, Department of Pharmacology, Sri Vijay Vidyalaya College of Pharmacy, Dharmapuri, India
  • A. Vasanthan Associate Professor, Department of Pharmaceutics, Sri Vijay Vidyalaya College of Pharmacy, Dharmapuri, India
  • S. Venkateshwaran Associate Professor, Department of Pharmacognosy, Sri Vijay Vidyalaya College of Pharmacy, Dharmapuri, India

Keywords:

IR–investigations, antibacterial and antifungal activities, 4-(5-chloro-1,3,4-oxadiazole-2-yl) benzenamine

Abstract

The 1,3,4-oxadiazole derivatives are aromatic heterocycles with low lipophilicity, which are useful in medication development. By replacing at the 2- and 5-positions, the heterocycle's electrical and hydrogen bond-accepting properties can be altered, allowing it to be used as a carbonyl bioisotere. The 1,3,4-oxadiazole derivative [4-(5chloro-1,3,4-oxadiazole-2-yl) benzenamine is formed when para-aminobenzoic acid is combined with ethyl alcohol to make para-aminoethylbenzoate, which then combines with hydrazine to form para-aminoethylbenzoate]. The structure of freshly synthesized compounds was determined using the IR method. Furthermore, for antibacterial and antifungal activity against all of the selected microbial strains, these compounds were compared to ciprofloxacin and ketoconazole, which served as the gold standard.

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Published

08-03-2022

How to Cite

[1]
P. D. Gokulan, K. L. S. Kumar, V. Suresh, A. Vasanthan, and S. Venkateshwaran, “Synthesis and Antimicrobial Screening of Some Substituted 1,3,4-Oxadiazole Derivatives”, IJRESM, vol. 5, no. 3, pp. 9–12, Mar. 2022.

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