Synthesis Characterization and Antimicrobial Activity of Some Novel Oxadiazole Derivatives

Authors

  • Rekha Birle Assistant Professor, Department of Pharmacy, Thakur Shivkumar Memorial Pharmacy College, Burhanpur, India
  • Archana Pachore Assistant Professor, Department of Pharmacy, Thakur Shivkumar Memorial Pharmacy College, Burhanpur, India
  • Nisha Hirve Assistant Professor, Department of Pharmacy, Charak Institute of Pharmacy College, Mandleshwar, India
  • Nisha Mandloi Assistant Professor, Department of Pharmacy, Thakur Shivkumar Memorial Pharmacy College, Burhanpur, India
  • Vinay Mahajan Assistant Professor, Department of Pharmacy, Thakur Shivkumar Memorial Pharmacy College, Burhanpur, India
  • Gajanand Engla Associate Professor, DAVV School of Pharmacy, Indore, India
  • Prernna Chaturvedi Assistant Professor, Department of Pharmacy, Swami Vivekanand Pharmacy College, Indore, India

Keywords:

Antimicrobial activity, Oxadiazole, Hydrazine hydrate, O-Phenylenediamine

Abstract

In the present study 1,3,4-Oxadiazole derivatives were synthesized and antimicrobial activities of different derivatives were checked with various microbial stains. Various intermediates were synthesized and characterized in between time-to-time by chromatographic and spectral methods. Substituted benzaldehyde and o-phenylenediamine were the starting material and finally formed of 1,3,4-oxadiazol-2-ylmethyl)-2-phenyl-1H- benzimidazole derivatives steps 1, dry acetone and ethyl chloro acetate react at room temperature and to of ethyl2phenyl1benzimidazole1yl) acetate 1,3,4-oxadiazole derivative have been synthesize from Schiff base of the corresponding hydrazine by using ethanol with reflex. finally treated with phosphorus chloride oxide to get the title compound. The structures of all the synthesized compound were established on the basic of elemental, chromatographic and spectral analysis. The synthesized compound was evaluated for their antimicrobial activity. The compound most active be against Escherichia coli and staphylococcus aureus.

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Published

02-04-2022

How to Cite

[1]
R. Birle, “Synthesis Characterization and Antimicrobial Activity of Some Novel Oxadiazole Derivatives”, IJRESM, vol. 5, no. 3, pp. 151–154, Apr. 2022.

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